Chronic mountain sickness in Chinese Han males who migrated to the Qinghai-Tibetan plateau: application and evaluation of diagnostic criteria for chronic mountain sickness

Chronic mountain sickness in Chinese Han males who migrated to the Qinghai-Tibetan plateau: application and evaluation of diagnostic criteria for chronic mountain sickness

BACKGROUND Chronic mountain sickness (CMS), originally characterized by excess hemoglobin (Hb), is currently diagnosed using score-based diagnostic criteria combined with excessive erythrocytosis and clinical symptoms. However, the current criteria have limited applicability. We applied these criteria to 1,029 Chinese Han males migrated to and have been stayed at the Qinghai-Tibet plateau (3,70...

Author's response to reviews Title:Chronic mountain sickness in Chinese Han males who migrated to the Qinghai-Tibetan plateau: application and evaluation of diagnostic criteria for chronic mountain sickness Authors:

SNPs, linkage disequilibrium, and chronic mountain sickness in Tibetan Chinese

Chronic mountain sickness (CMS) is estimated at 1.2% in Tibetans living at the Qinghai-Tibetan Plateau. Eighteen single-nucleotide polymorphisms (SNPs) from nine nuclear genes that have an association with CMS in Tibetans have been analyzed by using pairwise linkage disequilibrium (LD). The SNPs included are the angiotensin-converting enzyme (rs4340), the angiotensinogen (rs699), and the angiot...

Chronic Mountain Sickness

Introduction Chronic mountain sickness (CMS) affects people who are native or long time residents of high altitude. It is characterized by an excessive erythrocytosis for the altitude of residence, severe hypoxemia and in many cases, particularly in severe CMS, high altitude pulmonary hypertension (HAPH). CMS usually begins insidiously in adult life associated probably to aging; the clinical pi...

Chronic mountain sickness.

I read with great interest the article by White et al,’ which appeared in the July 1991 issue ofChest. The authors raised several important points concerning the utility of chest radiographs in adults admitted for exacerbations of bronchial asthma, I feel, however, that several aspects oftheir study must be addressed. First ofall, the study is relatively small (n =58) and uncontrolled, and invo...